• J.L.Agraz PhD

  • R&D Engineer

  • Inventor

  • Innovator

  • Author

Selected Publications

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Hyperpolarization Voltage Controlled Current Source

Improved PHIP Polarization using a Low Noise Precision Voltage Controlled Current Source

J Agraz, A Grunfeld, K Cunningham, S Wagner, D Li

Existing para-hydrogen induced polarization (PHIP) instrumentation relies on magnetic fields to hyperpolarize substances. These hyperpolarized substances have enhanced magnetic resonance imaging (MRI) signals ...

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Hyperpolarization Pinch Valve System

PHIP Instrumentation Pinch Valve System for Sample Delivery, Process and Collection

J Agraz, A Grunfeld, K Cunningham, S Wagner, D Li

Molecular imaging enables the in vivo visualization of cellular function. The hyperpolarization of substances used as endogenous imaging contrast agents allows for imaging at the molecular level. Hyperpolarization modalities ...

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Hyperpolarization LabView Software

LabVIEW-based control software for para-hydrogen induced polarization instrumentation

J Agraz, A Grunfeld, K Cunningham, S Wagner, D Li

The elucidation of cell metabolic mechanisms is the modern underpinning of the diagnosis, treatment, and in some cases the prevention of disease. ParaHydrogen induced polarization (PHIP) enhances magnetic ...

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Hyperpolarization LabView Software

Finger Force Sensor Instrumentation Design
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J Agraz, A Grunfeld, D Muse, R Pozos

Carpal tunnel syndrome (CTS) refers to a class of injuries characterized by compression of the median nerve in the carpal tunnel. CTS injuries cause pain, weakness, and numbness in the hands and are common among video ...

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Hyperpolarization LabView Software

LabVIEW based control software for Finger Force Sensor Instrumentation Design

J Agraz, R Pozos

This report describes National Instruments (NI) LabVIEW software for the control of finger force instrumentation for the quantification of Repetitive Stress Injury (RSI), Carpal Tunnel Syndrome (CTS), or other ...

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Hyperpolarization LabView Software

Effects of polarization rotation in the detection and tracking of orbiting objects using LabVIEW

J Agraz, A Grunfeld, D Muse, F Allston, R Pozos

The detection and tracking of orbiting space debris is vital for spacecraft safety and satellite longevity. The United States Air Force Space Surveillance System (AFSSS) uses a continuous wave (CW), multiplestatic...

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Hyperpolarization LabView Software

Delta-Shaped Piezoelectric Ultrasonic Motor for Two-Dimensional Positioning
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S Park, J Agraz, S Tuncdemir, Y Kim, R Eitel, A Baker

By fabricating on from lambda-shaped motors, bimorph delta-shaped motors have been developed and tested. A delta motor consists of two piezoelectric layers (bimorph structure) with four input electrodes and one common ...

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Hyperpolarization LabView Software

Quantitative Characterization of a Catalyzed PHIP Reaction
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S Wagner, J Agraz, D Li

Hyperpolarization by field cycling and RF transfer utilizing parahydrogen requires a fast addition of hydrogen to preserve the spin alignment of the parahydrogen. 1 To effectively utilize PHIP to produce the highest...

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Hyperpolarization LabView Software

Affordable Hyperpolarization by Parahydrogen Induced Polarization
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S Wagner, J Agraz, D Li

Knowledge of the longitudinal relaxation time (T1) of nanoparticles is useful for developing long lived nuclear magnetic resonance (NMR) signal for molecular targeting. Currently, dynamic nuclear polarization (DNP) has been ...

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Any sufficiently advanced technology is equivalent to magic
Arthur C. Clarke

Selected Patents

Most proud patents you might be interested in

Device and methods for para-hydrogen induced polarization

The invention teaches devices and methods for hyperpolarization by parahydrogen induced polarization

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Piezoelectric ultrasonic motor for 2-dimensional positioning

A piezoelectric ultrasonic motor having 2-dimensional positioning movement includes a stator

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Force measuring device and method

In one embodiment, a finger fatigue measuring system is provided which measures the force output from fingers while the fingers are repetitively generating forces as they strike a keyboard

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Fatigue monitoring device and method

The present invention relates to a device and method for monitoring fatigue

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Design is not just what it looks
and feels like. Design is how it works
STEVE JOBS

About me

services

Early Beginnings

I became fascinated by engineering research in my early teens. At the time, I put together a magnetic propulsion experiment using a piece of Styrofoam that I found on the beach and wire from an old transformer. As I plugged my device into the wall electrical outlet, my engineering career began with a spark!!

Education

I am a Big Ten fan, having attended Northwestern University (NU) in Chicago and Penn State University (PSU). Although I attended NU for the first two years of my PhD, our entire team transferred to Cedars-Sinai Medical Center (Cedars) in West-Hollywood, California, and I completed my degree at the University of California, Los Angeles (UCLA). While at Cedars, I conducted my graduate research in Magnetic Resonance Imaging (MRI) for breast & prostate cancer, imaging at the molecular level, with focus in hardware and software development. I received my master's in Electrical Engineering (EE) at PSU, with focus in electronic and piezoelectric material linear motors (PZT motors). I obtained a Code Division Multiple Access (CDMA) Engineering Certificate from the University of California, San Diego (UCSD), and the most fun course work I ever had in Radio Frequency (RF) Communications. I obtained my bachelor's in EE at San Diego State University (RF), with a focus in electronic circuit applications in electrophysiology and finger force measurements.

Engineering & Research

My first job as a teenager was working at Electromar as an electronic technician. I started out sweeping the shop, then moved on to programming in Basic and repairing Echo Sounders, Sonars, and Radars. It was the greatest job for an eager-to-learn engineering teenager like myself. My next jobs were with Helle Engineering, Ectron Corp, Air Force Space Surveillance System, (AFSSS) San Diego station (contractor), Cadence

Designs Systems (Cadence), and Testedge Inc (TE). As a technician at Helle Engineering, I learned to build and repair piezoelectric pingers for underwater detection and communication. Then, at Ectron, I became experienced in diagnosing, troubleshooting, and calibrating electronic circuits in Thermocouple simulators/calibrators. I also became skilled in Data Collection and Automation using HP Basic and GPIB. In my next position at the AFSSS, I learned the ins and outs of large scale remote sensing and satellite detection. I also began producing quality circuit designs, C/C++, and LabView software programs. Later, as a senior engineer at Cadence and Testedge, I became adept at Test Engineering with mixed signal circuit designs, high speed data collection, automation, and C/C++ programming. As a product design engineert at Intel Corp, I've focused on the quantification of physiological phenomena leading two fun projects: Precognition of Falls in the Elderly wearable and Global tracking of climate change through mangrove forest data collection access points in Costa Rica. In addition, I’ve split my time on Intel architecture CPU validation. During the pandemic, working as a Post-Doctoral Fellow at the University of Pennsylvania school of medicine, I've focused on "Big Data" analysis in a High Performance Computing (HPC) environment, developing algorithms for precision medicine through the digital quantification of diseased tissue in histopathology. More specifically, the use of image color normalization, statistical analysis, and machine learning techniques for the advancement of detailed Glioblastoma characterization, the most aggresive and deadly of brain cancers.

Today

Currently, Postdoctoral Fellow at the Wilson Lab, University of Pennsylvania School of Medicine (UPenn). My research focus is on analyzing big data concerning genomic changes in aging populations, with a particular focus on the loss of the Y-Chromosome in aging males and the unused X-Chromosome in aging females. This work aims to better understand the potential for developing kidney disease in these demographics. On a lighter note, I had the pleasure of hiking El Camino Frances over the summer (2022), from Saint-Jean-Pied-de-Port, France to Santiago de Compostela Spain. Covering 500 miles in 35 days was truly an unforgettable experience! See pictures here

For a successful technology, reality must take precedence over public relations, for Nature cannot be fooled
Richard P. Feynman

Selected R&D Projects

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Keep it simple, stupid
KELLY JOHNSOn

My R&D Engineering Work

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Copyright © 2015 Jose L. Agraz PhD / All rights reserved.